We previously identified DAMPs that are significantly altered in damaged human and murine tendons.20 In the context of tendinopathy, our data suggest HMGB1 is dysregulated in early disease and when released into the extracellular matrix promotes the production of proinflammatory cytokines IL-1β, IL-6 and IL-33. Here, HMGB1 is linked to disease of the tendon.