FADS2 and metabolic dysfunction-associated steatohepatitis: Regarding enzymes regulating fatty acid metabolism, a higher activity of delta-6 desaturase and stearoyl-CoA desaturase-1 and lower activity of delta-5 desaturase is reported in steatosis compared to non-steatosis [11], and in NASH compared to non-NASH, independently of obesity indexes and diet [12].