Our previous results showed that Wip1 deficiency can lead to the increased phosphorylation of p38, which can bind directly to CXCR2, thus decreasing the internalization of CXCR2 (20), all these results suggestd that Wip1 negatively regulated neutrophil migration into infection sites during sepsis through preventing CXCR2 internalization. This evidence concerns the gene CXCR2 and infection.