In addition, resistance to CLP-induced sepsis in Wip1 KO mice no longer existed after depletion of neutrophils with anti-Ly6G antibody (Figure 2D; Figure S2D in Supplementary Material), and neutrophil-depleted WT mice adoptively transferred with neutrophils from Wip1 KO BMCs also exhibited partially resistance to CLP-induced sepsis (Figure 2E). The gene discussed is PPM1D; the disease is Sepsis.