PPM1D and Sepsis: To explore the cellular mechanism accounting for the improved outcome of sepsis in Wip1 KO mice, complete chimeras were generated and results showed WT mice grafted with Wip1 KO BMCs displayed much more resistance to CLP-induced sepsis compared to WT mice grafted with WT BMCs (Figure 2A), indicating that Wip1 intrinsically controls hematopoietic cells to regulate sepsis.