CASP3 and Zika virus infectious disease: Approximately one third (28.0 ± 2.35%) of the cells present in the ZIKV-infected cultures were positive for the active form of caspase 3 (Figure 1A), compared to only 11.51 ± 1.43% of the cells in the MOCK-infected culture (Figure 1B), indicating that ZIKV infection triggers apoptosis.