Overall, HBsAg-specific responses were of higher magnitude, effector breadth and polyfunctionality than CSP-specific responses, suggesting a higher quality of response probably due to a booster effect since children should have been previously vaccinated with hepatitis B, or a higher immunogenicity of HBsAg compared to CSP due to the higher proportion of HBsAg than CSP in RTS,S (4:1). This evidence concerns the gene DNAJC5 and hepatitis B virus infection.