CD40LG and diabetes mellitus: In subsequent studies with murine models of inflammation, we showed that administration of intravenous polyclonal IgM, to increase plasma IgM-ALA levels in wild-type C57BL6 mice (referred to as WT-B6), attenuated the inflammatory response induced by innate (renal ischemia), adaptive (cardiac transplants), and autoimmune (diabetes mellitus in NOD mice)-mediated mechanisms (9, 15).