Also, the observed exposure-dependent reduced frequencies of TACI+ MZ-like B cells may jeopardize the production of long-lived antibody secreting cells (ASCs) at the expense of short-lived ASCs, as seen in malaria-exposed populations (66, 67) and is consistent with hypogammaglobulinemia, associated with deficiencies in TACI gene expression seen in common variable immunodeficiency disease (65). The gene discussed is TNFRSF13B; the disease is malaria.