GNRH1 and obesity due to melanocortin 4 receptor deficiency: Although obesity is known to accelerate growth in childhood, and an increase of one BMI unit is associated with a height gain of 0.29 cm in girls (38), our data shows that growth velocity prior to the evaluation of PP was a strong predictor for GnRH-dependent PP and could be used in the differential diagnosis between PT and PP within this age group.