PRKG1 and Right ventricular hypertrophy: Ramchandran et al. (2014) illustrated that a selective mutation in the NH2-terminus leucine zipper protein interaction domain of PKG-1, which mediates the interaction of PKG-1 with MYPT1 (Surks et al., 1999), resulted in progressive increases in RV systolic pressure and resultant right ventricular hypertrophy.