PPP1R12A and pulmonary arterial hypertension: In addition to the changes in LZ+/LZ− MYPT1 isoform expression, Konik et al. (2013) demonstrated that the expression of non-muscle (NM) myosin is significantly increased in MCT induced PAH, and Packer et al. (1998) showed that NM myosin expression also increases in pulmonary smooth muscle during hypoxia.