Interestingly, simulations after the reduction of total TNFR1 levels as indicated by our initial comparison of HCC cells and hepatocytes (Figure 1A, factor: 2.5) revealed a clear pathway dampening with regard to IκBα, phospho-p65, and IκBα mRNA amplitudes (Figure 2, yellow lines). The gene discussed is TNFRSF1A; the disease is hepatocellular carcinoma.