ESR1 and Hyperglycemia: Moreover, it is plausible to consider that the hyperglycemia altering negatively the balance of expression and activity of estrogen receptors (Dantas et al., 2012), which hold a positive role against the deleterious effects of angiotensin II (Xue et al., 2007), may be contributing to the elevated levels of angiotensin II and reduced levels of angiotensin 1–7 in the kidney of OB group when compared to the WT group.