Moreover, AGL in HepG2 cells probably by binding with adenosine A2α receptor activates Nrf-2 transcription and inhibited its exclusion from the nucleus by inactivating GSK-3β, together resulting in activation of HO-1, suggesting an application in the treatment of diabetes and other related diseases (Mittal et al., 2016). The gene discussed is HMOX1; the disease is diabetes mellitus.