Andrographolide and 14-deoxy-11,12-didehydroandro-grapholide (compound 6) in MES-13, an SV40-transformed murine glomerular mesangial cell line were evident to reduce the phenotypes indicating diabetic nephropathy, where AP2 showed potent activity than AGL in the reduction of apoptosis marker caspase-3, fibrosis marker TGF-β, and PAI-1. This evidence concerns the gene SERPINE1 and diabetic kidney disease.