As the NF-κB pathway represents one of the key inflammatory signaling pathways in the body, it is not surprising that there are many regulatory mechanisms to balance the host inflammatory response, including Cdc37 and Hsp90, which is important for TNFα-induced recruitment and IKKs complex activation, then resulting in NF-κB activation (Chen et al., 2002), Casein kinase 1α could also regulate activation of NF-κB signaling induced by antigen-receptor and the survival of human lymphoma cell (Bidere et al., 2009). Here, NFKB1 is linked to lymphoma.