Affected modules and related functions are associated with the pathological effects related to loss-of-function, and are known to be affected in Ppt1−/− mice, including pathological changes of a synaptic compartment (Virmani et al., 2005; Kielar et al., 2009; Peng et al., 2015; Tikka et al., 2016); moreover a severe epilepsy associated with typical Electroencephalogram (EEG) pattern (Santavuori, 1973) occurs in CLN1 patients, who are lacking PPT1 functional activity. Here, PPT1 is linked to epilepsy.