Further studies in either patient-derived iPSC motor neurons (Almeida et al., 2013) that exhibit C9orf72-haploinsufficiency or other models that express the C9orf72 ALS-associated GGGGCC expansion (Haeusler et al., 2016) could give more insight into the role of autophagy in C9orf72-ALS. This evidence concerns the gene C9orf72 and amyotrophic lateral sclerosis.