TARDBP and amyotrophic lateral sclerosis: In silico analyses of motor neurons from transgenic mutant SOD1 mice revealed ER stress to be an early pathological feature (Vlug et al., 2005; Atkin et al., 2006) In addition, ER stress has also been associated with TDP-43- and FUS-ALS (Vlug et al., 2005; Atkin et al., 2006).