As signal transducer and activator of transcription 3 (STAT3) and hypoxia-inducible factor 1 (HIF1) are the downstream molecules of the IL-6 signaling pathway, STAT3 activation has been observed in cancers and its activation in tumor cells plays a crucial role in mediating and promoting tumorigenesis [28–32]. This evidence concerns the gene HIF1A and neoplasm.