Furthermore, pharmacological blockade of apoptotic pathways of ERK1/2 or MEK 1/2 pathway, such as U0126 and selumetinib (AZD6244), significantly attenuated the pro‐apoptotic effects of field electric stimulation on the mutated Lamin A/C iPSC‐CMs35 and Lamin A/C -DCM mouse models36–38. This evidence concerns the gene MAPK3 and familial dilated cardiomyopathy.