ECHS1 and neoplasm: Moreover, ECHS1 knockdown in HepG2 (Fig. 10e) and ACHN cells (Fig. 10f) both resulted in facilitated tumor xenografts growth in mice, and putting back K/Q mutant into ECHS1 knockdown HepG2 and ACHN cells resulted in faster tumor xenografts growth than those of putting back the wild type and K/R mutant (Supplementary Fig. 22).