We also found that F2-Fc could specifically and significantly inhibit both HSP70-1A-dependent angiogenic functions and endothelial growth medium (EGM)-dependent HUVEC tube formation (Supplementary Fig. S6), leading us to speculate that this Fc fusion peptide may be a useful peptibody platform for suppressing tumor angiogenesis affected by various angiogenic factors. This evidence concerns the gene HSPA1A and neoplasm.