In the present study, we undertook a hypothesis-based approach to evaluate the impact of regulatory SNPs (rSNPs) in the core NER genes (ERCC1, ERCC2, ERCC3, ERCC4, ERCC5, RAD23B, XPA, XPC and XPE) on survival of NSCLC patients treated with PBC by analysing a pool of 25 rSNPs in 710 patients with advanced disease stages. The gene discussed is XPC; the disease is primary biliary cholangitis.