PGP and ovarian carcinoma: Moreover, GE retains similar activity in A2780/Taxol compared to the parental paclitaxel sensitive cell line A2780, and it downregulates the expression of P-gp in A2780/Taxol cells (Supplemental Fig. 1), suggesting it might show some prospects to overcome the multidrug-resistance of ovarian cancer cells, which needs to be further investigated.