The result (Fig. 2e) showed that A549 cells transduced with shRNA-MNK2 inhibited tumor growth significantly compared with those transduced with shRNA-NC when measured from the 10th day (*P < 0.05, **P < 0.01); moreover, the mean tumor weight was lower in cells transduced with shRNA-MNK2 than in those transduced with shRNA-NC (*P < 0.05). This evidence concerns the gene MKNK2 and neoplasm.