In prostate cancer cells, the relative activity of AKT/mTOR and MNK/eIF4E pathways are under a controlled balance; mTOR and MNK concomitant inhibition had higher suppression of prostate cancer cell cycle progression and cell proliferation than inhibition of only one of them via phosphorylated eIF4E9. The gene discussed is EIF4E; the disease is prostate carcinoma.