For example, hepatic 5α-reduction is the predominant clearance pathway for cortisol in humans but the product of this pathway, 5α-tetrahydrocortisol (5α-THF), is a selective GR modulator which may contribute to anti-inflammatory signaling12; inhibition of 5α-reductase type 1 results in glucose intolerance and liver fat accumulation, likely due to increased cortisol action in liver or skeletal muscle13. This evidence concerns the gene NR3C1 and Glucose intolerance.