To test whether O-GlcNAcylation of p53/c-Myc is a potential regulator of CDDP-induced apoptosis in lung cancer cells under specified context, NCI-H460 and NCI-H292 cells were ectopically transfected with p53 and c-Myc, respectively, and apoptosis in response to CDDP and KCZ co-treatment was determined. This evidence concerns the gene TP53 and lung cancer.