Furthermore, using an organotypic model of perfusable microvessels, we demonstrate that tumor-derived Lin-EpCAM-CD73+CD90+ mesenchymal cells (herein referred to as perivascular-like) specimens support microvessel formation, upregulate αSMA upon contact with microvessels, but lead to higher microvascular permeability compared to their matched normal counterparts. Here, NT5E is linked to neoplasm.