APOBEC3B and neoplasm: Next, we used our RNA-Seq data to analyze the correlation between the various genotypes and the expression levels of A3A and A3B. As shown in Fig. 4b and Supplementary Fig. 13, A3A expression was significantly elevated in tumor tissues compared to adjacent normal tissues from all three genotypes; moreover, the level was about 2-fold higher in carriers of the A3B−/− genotype compared to those harboring the A3B+/− and A3B+/+ genotypes.