IFIT1 and melanoma: Upregulation of interferon response genes in multiple melanoma cell lines by ganetespib was confirmed by quantitative real time PCR and Western blot analyses, most strongly for members of the IFN-induced protein with tetratricopeptide repeats (IFIT) gene family: IFIT1, IFIT2 and IFIT3 (Fig. 2b, c and Supplementary Fig. 4A, B).