The LAM-induced maturation of spleen and tumor draining lymph nodes (drLN) and dendritic cells (DCs) in in vivo tumor microenvironments were investigated, and the results showed that the laminarin-induced maturation of both CD8α+ and CD8α cDCs promoted antigen (Ag) specific T helper 1 (Th1) and cytotoxic T lymphocyte (CTL) immune responses. Here, CD8A is linked to neoplasm.