Principal components analysis (PCA) revealed no significant separation between four pairwise comparisons (Plin2-HF vs. Plin2-LF; Plin2-HF vs. WT-HF; Plin2-LF vs. WT-LF; and WT-HF vs. WT-LF—non-parametric multiple analysis of variance (PERMANOVA); Additional file 3: Figure S1A). This evidence concerns the gene PLIN2 and hydrops fetalis.