PLIN2 and hydrops fetalis: In comparison, microbiota of Plin2 mice exhibited a global upregulation of most enriched pathways under a HF diet with 24 of 42 pathways exhibiting > 10-fold change, suggesting that the microbiota of Plin2-null mice either were more sensitive than WT to increased dietary fat or that Plin2 deletion altered the physiological and/or nutritive landscape of the gut.