For example, the increased abundance of Lachnospiraceae reads and enrichment in differentially expressed transcripts in three of four comparisons (i.e., Plin2 vs. WT on HF diet, Plin2 vs. WT on LF diet, and Plin2 on HF vs. LF diet; Geno-HF, Geno-LF, and Diet-Plin2 panels, respectively, in Fig. 2a) is consistent with our previous 16S-based study, which suggested an increased abundance of this taxon, albeit without statistical significance, under a HF diet for both Plin2 and WT mice [32]. Here, PLIN2 is linked to hydrops fetalis.