When considering Hh signaling proteins in the epithelium, we observed that low levels of PTCH1 and GLI3 expression were more likely to occur in tumor tissue than in benign (PTCH1 76% PCa versus 26.6% benign, and GLI3 55.2% versus 29%, respectively, p < 0.001). Here, PTCH1 is linked to posterior cortical atrophy.