POMC and Cushing syndrome due to macronodular adrenal hyperplasia: Adrenocoricotrophic hormone (ACTH) – independent bilateral adrenocortical macronodular hyperplasia (AIMAH) is a disease which shows Cushing’s syndrome or preclinical Cushing’s syndrome due to autonomous cortisol secretion, and is characterized by bilateral adrenal hyperplasia [1].