SOD1 and amyotrophic lateral sclerosis: We found that homogenates prepared from SOD1-FALS spinal cord tissues can trigger 30–40% more aggregation compared to homogenates from sporadic ALS patients, or 16–25% more compared to control samples, in all three G37R, G85R and G93A-based chimeric reporter proteins following 48 h incubations (Fig 1B and 1C).