When SUVmax combined with all the serum tumor markers, the AUC increased to 0.902, which was significantly higher than those of SUVmax (Z = 2.357, P = 0.018), CEA (Z = 2.800, P = 0.005), CYFRA21-1 (Z = 3.326, P<0.001), SCC-Ag (Z = 4.863, P<0.001) and NSE (Z = 2.767, P = 0.006), and was higher than that of combined tumor markers (Z = 0.841, P = 0.401). This evidence concerns the gene ENO2 and neoplasm.