ENO2 and neoplasm: When SUVmax combined with all the serum tumor markers, the AUC increased to 0.916, which was significantly higher than those of SUVmax (Z = 6.819, P<0.001), CEA (Z = 5.880, P<0.001), CYFRA21-1 (Z = 5.141, P<0.001), SCC-Ag (Z = 6.036, P<0.001) and NSE (Z = 2.311, P = 0.021), and was slightly higher than that of combined tumor markers (Z = 0.139, P = 0.890).