IRFs exert their functions through various molecular mechanisms including: (i) regulation of type 1 IFN expression via toll-like receptor signaling [18]; (ii) interaction with the NF-κB signaling pathway [19]; and (iii) interaction with the mammary serine protease inhibitor (maspin), which is regarded as a tumor suppressor [20]. This evidence concerns the gene SERPINB5 and neoplasm.