RIG-I (encoded by the DDX58 gene), a pattern recognition receptor for viral RNA, and MAVS, which mediates the activation of NFKB and IRF3 in response to viral infection [61], both key molecules in the cellular innate immune response, are activated to a lesser extent by NH1067B and other “low inducers” as compared to NH1125B and other “high inducers” at early times post infection (Fig 6C). Here, MAVS is linked to viral infectious disease.