In the model without X-inactivation, the last SNPs in rs5942424-rs2206685-rs12556066-rs10521385 (Xq21.3) is located ~109 kb from ‘CPX chromosome region, candidate 1’ (CPXCR1)—one among several genes associated with X-linked cleft palate (CPX) [27]. This evidence concerns the gene TBX22 and cleft palate with or without ankyloglossia, X-linked.