As also noted by Wise et al. [7], PJA1 lies ~318.6 kb upstream of ‘Ephrin-B1’ (EFNB1) and ~450.5 kb downstream of ‘Ectodysplasin A’ (EDA)—between two genes already implicated in orofacial clefts. Here, PJA1 is linked to orofacial cleft.