Whether the activity of SUR1/Trpm4 channels in NPY neurons is modulated by pathologic, inflammatory conditions is not known, but it is worth pointing out that upregulation and/or increased activity of these channels is associated with neuroinflammation in CNS models [92,93,94], while inflammation within the hypothalamus is associated with obesity (e.g., [95,96,97,98]). The gene discussed is ABCC8; the disease is obesity due to melanocortin 4 receptor deficiency.