This also appeared true in our model, as enforced expression of MYC rescued the proliferation and differentiation phenotypes observed upon depletion of Pvt1. Although the same phenotype, including Myc-mediated rescue, was also observed for two other lncRNAs (Lilam and Pilna) in leukemia, only Pilna showed an effect in normal reconstitution of the myeloid lineage. Here, MYC is linked to leukemia.