PVT1 and leukemia: This also appeared true in our model, as enforced expression of MYC rescued the proliferation and differentiation phenotypes observed upon depletion of Pvt1. Although the same phenotype, including Myc-mediated rescue, was also observed for two other lncRNAs (Lilam and Pilna) in leukemia, only Pilna showed an effect in normal reconstitution of the myeloid lineage.