In accordance with our hypothesis, transitory hypothyroidism during demyelination, followed by T3/T4 pulses (Figure 1A) to favor oligodendrocyte maturation (Barres et al., 1994), increased Myelin Basic Protein (MBP) and Myelin Oligodendrocyte (MOG), two markers of maturing oligodendrocytes, in the corpus callosum and septum (Figure 1B and Figure 1—figure supplement 1B,E,F). This evidence concerns the gene MBP and hypothyroidism.