Ischemia/reperfusion (I/R) showed the elevated level of caspase-12 and ER stress markers in myocardium [46, 51–53], and the expression of caspase-12 and cleaved caspase-3 were abnormally altered in the pathological cardiac hypertrophy in rodent model [54, 55]. The gene discussed is CASP12; the disease is cardiac hypertrophy.