CDH1 and neoplasm: Also, in Dr. Anbiaee et al.’s study in Iran, a correlation between E-cadherin mutation and the grade and lymph node involvement was seen, but this marker was not correlated with depth of invasion.20 In Dr. Saad et al.’s study in Egypt, there was a significant correlation between this marker and lymph node involvement and tumor stage, but the depth of invasion and tumor grade were not linked.22In Dr. Chu et al.’s study in China, a correlation between depth of invasion and lymph node involvement was seen, but it was not associated with grade.17