AKT1 and medulloblastoma: Also, the study on the effect of CUR on β-catenin in human neuroblastoma cell line SH-SY5Y has shown an apparent increase in the expressionof mRNA and protein level of β-catenin and PI3K/AKT.30,31Similarly, CUR by activation of GSK-3βmay reduce the expression of β-catenin and its downstream target cyclin D1 in medulloblastoma.