APAF1 and neoplasm: Apoptotic protease activating factor1 (APAF1),a putative TSG, encodes one of the important cytoplasmic proteins in DNA damage – induced apoptosis and is therefore essential for tumor suppression.6,7 In apoptotic cascade, cytochrome C released from the mitochondria in response to cell death stimulus is bound to APAF1in the cytosol.