Importantly, the biodistribution study using human pancreatic cancer mouse model with engineered mutant KrasG12D activation revealed the uptake of 125I-anti-PRR was markedly elevated in pancreas of Pdx1-cre; LSL-KrasG12D mice than WT control littermates at 4 months of age. This evidence concerns the gene ATP6AP2 and familial pancreatic carcinoma.