Consistently, in vivo we radioiodinated and evaluated a PRR antibody in mice harboring subcutaneous Panc-1, ASPC, Miapaca, HPAC, and BXPC-3 pancreatic tumors xenografts using SPECT/CT and found that Panc-1 and ASPC tumors uptake and retention of radioactivity with the 125I-anti-PRR had significantly increased than others. Here, ATP6AP2 is linked to pancreatic neoplasm.