CCN2 and neoplasm: In addition to CD146, UCA-PSCs and UCV-PSCs both expressed higher levels of angiogenesis-related genes than WJ-MSCs, such as ISL1, JAG1, THBS1, CXCL12, CTGF, HIF1A, and ERAP1. It was reported that Jagged1 overexpression in tumor cells enhances neovascularization and tumor growth and that loss of Jagged1 in endothelial had an inhibitory effect on the neoangiogenic and maturation responses as well as an angiocrine effect in tumor cells [39].