LRRC26 and cystic fibrosis: In cystic fibrosis (CF), TGF-β1 has been described to cause mucociliary dysfunction by reducing ASL volume via decreased apical BK channel activity11 through a down-regulation of Leucine Rich Repeat Containing protein 26 (LRRC26), the γ subunit necessary for BK function in non-excitable tissues30.