MLKL and infection: We detected a weak 50 kDa band of cleaved PARP that is considered a maker for necrosis71, and FPR1−/− mice had greatly reduced splenic cell death, although treatment of mice with necrostatin-1/GW806742X (p-MLKL inhibitor)/ferrostatin-1 and infection of caspase1/caspase11 double KO mice did not significantly change host survival rate.