The third and fourth most highly mutated putative driver DHSs in breast cancer are at chr8:579137-581436, which was associated in Filter 3 with ZNF596 downregulation, a gene frequently downregulated in breast cancer37 and osteosarcoma38; and at chr20:62115827-62119284 which was associated with the overexpression of five genes, including ARFGAP1, a gene involved in microsatellite instability oncogenesis39, and COL20A1, whose expression levels are used in predictive models for breast cancer risk40. The gene discussed is ARFGAP1; the disease is breast carcinoma.