In order to detect driver DHSs that are important across all four clinical phenotypes we obtained whole-genome sequences from TCGA for 47 breast cancers (and matched normal samples), representing all four categories (4 HR−/HER2+, 6 HR+/HER2−, 15 HR+/HER2+ and 22 triple negative, Supplementary Fig. 1, Supplementary Table 1). The gene discussed is HR; the disease is breast cancer.