Four of these genes have known associations with cancer: TERT overexpression is associated with glioblastoma, hepatocellular carcinoma and melanoma1; CLPTM1L inherited variants are associated with lung and pancreatic cancer risk28; overexpression of TRIP13 drives DNA damage in head and neck cancer29; and LPCAT1 overexpression correlates with tumor progression and prognosis in breast, colorectal and prostate cancer30. Here, TERT is linked to familial pancreatic carcinoma.