TERT and breast cancer: Nik-Zainal et al.2 analyzed the mutational landscape of 560 breast cancers and also found putative driver mutations in the promoters of PLEKHS1 and WDR74, as well as in the promoter of TBC1D12. Fredriksson et al.3 focused on regions immediately upstream of transcription start sites, identified 17 recurrent promoter mutations and characterized mutations in the TERT promoter.