Thus, the results show that the expression of the susceptible CmVPS41allele in the resistant SC accession allows CMV systemic infection and, therefore, that CmVPS41 protein is indeed encoded by Cmv1. The limited infection by CMV-LS suggests that as the transgenic lines are tetraploid, and they may carry only one copy of the susceptible allele, the limited amount of PS CmVPS41 protein could be a limiting factor for CMV-LS infection. The gene discussed is LIAS; the disease is Leigh syndrome.