YAP1 and neoplasm: Downregulation of YAP1 resulted in reduced cell proliferation (Supplementary Fig. 4e), reduced expression of pro-survival protein BIRC5 and upregulation of apoptotic markers such as cleaved-caspase3 (Supplementary Fig. 4f), suggesting that YAP1 expression was indeed necessary for survival of HN137-Met tumour cells.